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Xanax is for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety and panic disorders with or without agoraphobia. Tension or anxiety related with the stress of everyday life usually does not require treatment with an anxiolytic. Ansiety associated with depression is also responsive to Xanax.
Overdosage reports with alprazolam immediate release tablets are limited.
Evident alprazolam overdosage include somnolence, confusion, impaired coordination, diminished reflexes and coma. Death has been reported in connection with overdoses of alprazolam by itself, as it has with other benzodiazepines. Fatalities have also been reported in patients who have overdosed with a combination of a single benzodiazepine including alprazolam and alcohol. Levels of alcohol seen in some of these patients have been lower than those usually associated with alcohol-induced fatality.
No delayed reactions (organ toxicity) or clinical laboratory abnormalities have been reported.
Like in cases of drug overdosage, respiration, pulse rate and blood pressure should be monitored. General supportive measures must be employed together with immediate gastric lavage. Administration of intravenous fluids and an adequate airway maintained should be done. Hypotension may be combated by the use of vasopressors, Levophed (levanterenol) or Aramine (metaraminol). Like in the management of intentional overdosing with any drug, it should be borne in mind that multiple agents may have been ingested.
Xanax is contraindicated to patients with known sensitivity to Xanax or other benzodiapines. Xanax may be used in patients with open-angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute anrrow-angle glaucoma. Xanax XR is contraindicated with ketoconazole and itraconazole, since these medications significantly impair the oxidative metabolism mediated by cytochrome P-450 (CYP3A).
Xanax is of no value in the treatment of psychotic patients and should not be employed in lieu of appropriate treatment for psychosis.